MMS 8140

The overall goal of the course is to provide a description of the structures and biosynthetic origins of natural products of marine origin. The main classes of natural products will be reviewed with an emphasis on their biological origin as a tool to understanding structures. The biomedical relevance of marine natural products will be discussed along with special topics lectures on such themes as "From lead compound to FDA approval" and "Development of a natural product drug lead". Additional lectures on biological screening and metabolomics as modern tools in drug discovery, and chromatographic purification of natural products will round out the discussions. Students will be expected to develop a thorough understanding of the biosynthetic origin of all major categories of natural products through case studies. Cross-listed with Chemistry 4140. Credit cannot be received for both MMS 8140 and CHEM 4140. Admission to graduate program in Science.